Low-Cost Piezoelectric Sensors for Time Domain Load Monitoring of Metallic Structures During Operational and Maintenance Processes

The versatility of piezoelectric sensors in measurement techniques and their performance in applications has given rise to an increased interest in their use for structural and manufacturing component monitoring. They enable wireless and sensor network solutions to be developed in order to directly integrate the sensors into machines, fixtures and tools. Piezoelectric sensors increasingly compete with strain-gauges due to their wide operational temperature range, load and strain sensing accuracy, low power consumption and low cost. This research sets out the use of piezoelectric sensors for real-time monitoring of mechanical strength in metallic structures in the ongoing operational control of machinery components. The behaviour of aluminium and steel structures under flexural strength was studied using piezoelectric sensors. Variations in structural behaviour and geometry were measured, and the load and μstrains during operational conditions were quantified in the time domain at a specific frequency. The lead zirconium titanate (PZT) sensors were able to distinguish between material types and thicknesses. Moreover, this work covers frequency selection and optimisation from 20 Hz to 300 kHz. Significant differences in terms of optimal operating frequencies and sensitivity were found in both structures. The influence of the PZT voltage applied was assessed to reduce power consumption without signal loss, and calibration to μstrains and loads was performed.This research was funded by Basque Government, grant number KK-2019/00051-SMARTRESNAK and by the European Commission, grant number 869884- RECLAIM

Impact of urinary catheter on resistance patterns and clinical outcomes on complicated urinary tract infection

Q4Q1Pacientes con Infección complicada del tracto urinarioIntroduction and hypothesis: Complicated urinary tract infection (cUTI) is highly prevalent and costly for health systems. The impact of the indwelling urinary catheter on etiologic agents and clinical outcomes has been poorly studied in Latin America. Methods: Cross-sectional study including patients with cUTI, with positive urine culture, treated at Hospital Universitario San Ignacio, Bogotá (Colombia) between 2017 and 2020. Clinical and microbiologic characteristics, treatments and outcomes are explored, comparing those with and without indwelling urinary catheter. Results: Seven hundred thirty-five patients with non-catheter-associated cUTI (NC-cUTI) and 165 with catheter-associated cUTI (CAUTI) were included. CAUTI group had a higher proportion of recurrent UTI (18% vs 33.3%, p 30 days unplanned readmission rate (5.8% vs 10.3%, p < 0.001). In the same group, we found a higher frequency of Pseudomonas spp (2.6% vs 9.4%, p < 0.001), Enterococcus spp. (2.4% vs 3.3%, p = 0.016), Serratia marcescens (0.6% vs 3.3%, p < 0.001) and Citrobacter freundii (0.5% vs 5.7%, p < 0.001). It implied a higher number of patients treated with fourth-generation cephalosporins (1.4% vs 4.8%, p = 0.004), ertapenem (32.9% vs 41.8%, p = 0.027) and carbapenems associated with a second antibiotic (1.9% vs 8.5%, p < 0.001). Conclusions: Patients with CAUTI have a higher frequency of resistant germs, require greater use of resources and have worse clinical outcomes than patients who do not require such devices. Measures should be strengthened to minimize its use, in both the hospital and outpatient setting.https://orcid.org/0000-0002-6392-7554https://orcid.org/0000-0001-5401-0018https://orcid.org/0000-0001-8658-6513https://orcid.org/0000-0001-6396-3267Revista Internacional - IndexadaA1N

Auscultación de presas y su aplicación al estudio de gradientes hidráulicos

Las características morfológicas de la Presa de Las Fitas, presa de materiales sueltos con núcleo de arcilla. Así como las propias del terreno en que se ubica (compuesto por un sustrato terciario dominado por argilitas y limolitas con paquetes intercalados de arenisca de pequeño espesor), obliga a tener controladas en todo momento las filtraciones de agua a través del cimiento de la presa. Para ello se disponen de una serie de elementos de auscultación que de modo continuo están recogiendo información, tanto del cuerpo de presa como de sus interacciones con distintos elementos del contorno. En base a los datos de necesario control para prevenir y salvaguardar la integridad de la presa, se diseñaron unas secciones tipo con la distinta instrumentación que se requería. Del mismo modo, aguas abajo y fuera del cuerpo de presa, se disponen aforadores que permiten controlar las filtraciones a través de la cerrada. Con el análisis de los datos de esta instrumentación, especialmente en la fase de puesta en carga, se obtienen una serie de conclusiones que van a condicionar la futura explotación del embalse

New Image Recognition Technique for Intuitive Understanding in Class of the Dynamic Response of High-Rise Buildings.

In the last years, more and more studies have highlighted the advantages of complementing traditional master classes with additional activities that improve students’ learning experience. This combination of teaching techniques is specially advised in the field of structural engineering, where intuition of the structural response it is of vital importance to understand the studied concepts. This paper deals with the introduction of a new (and more encouraging) educational tool to introduce students intuitively to the dynamic response of structures excited with an educational shaking table. Most of the educational structural health monitoring systems use sensors to determine the dynamic response of the structure. The proposed tool is based on a radically different approach, as it is based on low-cost image-recognition techniques. In fact, it only requires the use of an amateur camera, a black background, and a computer. In this study, the effects of both the camera location and the image quality are also evaluated. Finally, to validate the applicability of the proposed methodology, the dynamic response of small-scale buildings with different typologies is analyzed. In addition, a series of surveys were conducted in order to evaluate the activity based on student´s satisfaction and the actual acquisition and strengthening of knowledgepost-print8992 K

Estresores adolescentes: Desarrollo de la versión española del Adolescent Stress Questionnaire (ASQ-S)

El propósito del presente trabajo es estudiar las propiedades psicométricas de la versión española del Adolescent Stress Questionnaire (ASQ-S) para evaluar los estresores contemporáneos que experimenta la población adolescente entre 12 y 18 años.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110

BACKGROUND: In the search for novel antibody-drug conjugates (ADCs) with therapeutic potential, it is imperative to identify novel targets to direct the antibody moiety. CD13 seems an attractive ADC target as it shows a differential pattern of expression in a variety of tumors and cell lines and it is internalized upon engagement with a suitable monoclonal antibody. PM050489 is a marine cytotoxic compound tightly binding tubulin and impairing microtubule dynamics which is currently undergoing clinical trials for solid tumors. METHODS: Anti-CD13 monoclonal antibody (mAb) TEA1/8 has been used to prepare a novel ADC, MI130110, by conjugation to the marine compound PM050489. In vitro and in vivo experiments have been carried out to demonstrate the activity and specificity of MI130110. RESULTS: CD13 is readily internalized upon TEA1/8 mAb binding, and the conjugation with PM050489 did not have any effect on the binding or the internalization of the antibody. MI130110 showed remarkable activity and selectivity in vitro on CD13-expressing tumor cells causing the same effects than those described for PM050489, including cell cycle arrest at G2, mitosis with disarrayed and often multipolar spindles consistent with an arrest at metaphase, and induction of cell death. In contrast, none of these toxic effects were observed in CD13-null cell lines incubated with MI130110. Furthermore, in vivo studies showed that MI130110 exhibited excellent antitumor activity in a CD13-positive fibrosarcoma xenograft murine model, with total remissions in a significant number of the treated animals. Mitotic catastrophes, typical of the payload mechanism of action, were also observed in the tumor cells isolated from mice treated with MI130110. In contrast, MI130110 failed to show any activity in a xenograft mouse model of myeloma cells not expressing CD13, thereby corroborating the selectivity of the ADC to its target and its stability in circulation. CONCLUSION: Our results show that MI130110 ADC combines the antitumor potential of the PM050489 payload with the selectivity of the TEA1/8 monoclonal anti-CD13 antibody and confirm the correct intracellular processing of the ADC. These results demonstrate the suitability of CD13 as a novel ADC target and the effectiveness of MI130110 as a promising antitumor therapeutic agent.This work was partially supported by grant IPT-2012-0198-090000 (“MARINMAB” project) from Ministerio de Economía y Competitividad (MINECO) and European Regional Development’s funds (ERDF) and by CSIC grant 2019AEP146.S

Constructing virtual 5-dimensional tori out of lower-dimensional network cards

[EN] In the Top500 and Graph500 lists of the last years, some of the most powerful systems implement a torus topology to interconnect themillions of computing nodes they include. Some of these torus networks are of five or six dimensions, which implies an additional difficulty as the node degree increases. In previous works, we proposed and evaluated the nD Twin (nDT) torus topology to virtually increase the dimensions a torus is able to implement. We showed that this new topology reduces the distances between nodes, increasing, therefore, global network performance. In this work, we present how to build a 5DT torus network using a specific commercial 6-port network card (EXTOLL card) to interconnect those nodes. We show, using the same number of cards, that the performance of the 5DT torus network we are able to implement using our proposal is higher than the performance of the 3D torus network for the same number of compute nodes.Spanish MINECO; European Commission, Grant/Award Number: TIN2015-66972-C5-1-R and TIN2015-66972-C5-2-R; JCCM, Grant/Award Number: PEII-2014-028-P; Spanish MICINN, Grant/Award Number: FJCI-2015-26080Andújar-Muñoz, FJ.; Villar, JA.; Sanchez Garcia, JL.; Alfaro Cortes, FJ.; Duato Marín, JF.; Fröning, H. (2017). Constructing virtual 5-dimensional tori out of lower-dimensional network cards. Concurrency and Computation Practice and Experience. 1-17. https://doi.org/10.1002/cpe.4361S11

Evaluación de estado físico, antropométrico y biomarcadores en árbitros de fútbol del departamento del Quindío.(Original)

Objective: to determine the anthropometric profile, the physical condition and the behavior of biomarkers associated with physical load in ranked soccer referees from Quindío’s region. Methodology: there was participation of 14 referees (9 assistants and 5 main referees); whose body composition was estimated through the 4-component model, in addition to health indices as physical condition variables which were evaluated: flexibility, strength, speed and resistance; this last variable was measured through the intermittent level 1 YOYO test, where maximum heart rate and the recovery associated with it were measured, the subjective perceived exertion (RPE), mass and urine specific gravity (USG) to determine the state of hydration in the test. Results: Among the main results, it was found that, with respect to the health marker groups, the referees were in the ranges considered normal, in the characterization of the physical condition, no statistical significance was found between (assistant referees and main referees). Regarding the behavior of physical load markers, it was observed that the maximum heart rate was 188 and 181 bpm on average for main and assistant referees, respectively, without statistical significance. The recovery after the stimulus occurred in a decreasing way and in each of the shots showed statistical significance with respect to the previous one. The RPE was classified as a very heavy effort. Finally, regarding the state of hydration, it was shown that, although the mass, pre and post, presented a statistically significant difference, the same did not occur with respect to USG. Conclusion: although the main referees presented better physical condition results than the assistant referees, these differences were not statistically significant. Regarding physical load biomarkers, they behaved similarly in both groups.Objetivo: determinar el perfil antropométrico, de condición física y el comportamiento de biomarcadores asociados a la carga física en árbitros de fútbol escalafonados del departamento de Quindío. Metodología: participaron 14 árbitros (9 asistentes y 5 centrales); a los cuales se les estimó la composición corporal a través del modelo de 4 componentes, además índices de salud; como variables de condición física fueron evaluadas flexibilidad, fuerza, velocidad y resistencia, esta última a través del test YOYO de recuperación intermitente nivel 1, en este test de resistencia se midió la frecuencia cardiaca máxima y la recuperación asociada a esta, también se evaluó la percepción subjetiva del esfuerzo (PSE), masa y gravedad específica de la orina (GEO) para determinar el estado de hidratación en el test. Resultados:Dentro de los principales resultados se encontró que, con respecto a los marcadores de salud, los árbitros se encontraron en los rangos considerados como normales, en la caracterización de la condición física, no se encontró significancia estadística entre grupos (árbitros asistentes y árbitros centrales). En relación con el comportamiento de marcadores de carga física, se pudo apreciar que la frecuencia cardiaca máxima fue de 188 y 181 ppm en promedio para árbitros centrales y asistentes respectivamente, sin significancia estadística. La recuperación post estímulo se dio de forma decreciente y en cada una de las tomas mostró significancia estadística con respecto a la anterior. La PSE se clasificó como un esfuerzo muy pesado. Finalmente, con respecto al estado de hidratación se observó que, aunque la masa, pre y post presentó diferencia estadísticamente significativa, no ocurrió lo mismo con respecto a GEO. Conclusión:aunque los árbitros centrales presentaron mejores resultados de condición física que los árbitros asistentes, estas diferencias no fueron estadísticamente significativas. Con respecto a los biomarcadores de carga física, estos se comportaron de manera similar en ambos grupos

A DNA Microarray-Based Assay to Detect Dual Infection with Two Dengue Virus Serotypes

Here; we have described and tested a microarray based-method for the screening of dengue virus (DENV) serotypes. This DNA microarray assay is specific and sensitive and can detect dual infections with two dengue virus serotypes and single-serotype infections. Other methodologies may underestimate samples containing more than one serotype. This technology can be used to discriminate between the four DENV serotypes. Single-stranded DNA targets were covalently attached to glass slides and hybridised with specific labelled probes. DENV isolates and dengue samples were used to evaluate microarray performance. Our results demonstrate that the probes hybridized specifically to DENV serotypes; with no detection of unspecific signals. This finding provides evidence that specific probes can effectively identify single and double infections in DENV samples

Análisis del uso de autoevaluaciones en una plataforma digital en el entorno de la Fsiologia Médica

[EN] In the Medicine School of Universidad CEU San Pablo, a group of professor involving in the Physiology area is actively engaged in updating the teaching methodology to be used. To this end, in the last years we have tried to encourage the acquisition of different competences by students such as: increasing their autonomy to manage their progress in this area, finding information in various sources, managing different communication modalities and collaborative work. The aim of these objectives is to expand students' skills so that they can deepen the acquisition of knowledge and promote their dissemination in the academic environment. With this intention, in the last years we have presented to the students different learning tools, and in this report we show the results obtained from the analysis and reflection of the realization of self-evaluations in the platform Blackboard among all Physiology students in this academic year 2016-2017[ES] En la asignatura de Fisiología I del Grado de Medicina los profesores están comprometidos de forma activa en actualizar la metodología docente a utilizar. En los últimos años, se ha fomentado que el alumno adquiriera distintas competencias como son: el aumento de su autonomía para gestionar su progreso en la asignatura, la búsqueda de información en fuentes diversas, el manejo de distintas modalidades de comunicación y el trabajo colaborativo. El objetivo de estas competencias está dirigido a que amplíen sus destrezas para profundizar en la adquisición de los conocimientos y que sean capaces de divulgarlos en el entorno académico. Con esta intención, en la asignatura de Fisiología, se han ofrecido a los alumnos distintas herramientas de aprendizaje, y en la presente memoria se aborda el análisis sobre la realización de autoevaluaciones en la plataforma BlackBoard y el grado de utilidad que los alumnos han otorgado a esta herramienta de aprendizaje.Escudero Lirola, E.; Sanchez-Vera, I.; Barhoum, R.; Puche, JE.; Muñoz, Ú. (2017). Análisis del uso de autoevaluaciones en una plataforma digital en el entorno de la Fsiologia Médica. En In-Red 2017. III Congreso Nacional de innovación educativa y de docencia en red. Editorial Universitat Politècnica de València. 1229-1232. https://doi.org/10.4995/INRED2017.2017.6809OCS1229123